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IUSM Scope

August 10, 2012
Volume 16 Number 31 • Indianapolis, Indiana

Topics this issue:

Above the Fold

Arrow IU Neurosciences Research Building begins construction with ceremony

Indiana Gov. Mitch Daniels and IU Presdent Michael A. McRobbie joined leaders from the IU School of Medicine and IU Health on Aug. 6, for a groundbreaking ceremony at the IUPUI Campus Center Theater that recognized the start of construction on the IU Neurosciences Research Building. Complete video and photos from the event are online.

The building, scheduled to open in 2014, will complete the second phase of the IU Health Neuroscience Center at West 16th Street and North Senate Avenue. It will provide IUSM scientists, including researchers from the Institute of Psychiatric Research and the Stark Neurosciences Research Institute, with state-of-the-art facilities in which to conduct a broad range of neuroscience research in fields such as neurotrauma, dementias, addiction, epilepsy and pain.

"The start of work on this new research building is the culmination of a longstanding vision for a center that will bring together the talents of neuroscientists in many fields to work closely with each other and with their colleagues providing patient care,” said D. Craig Brater, M.D., dean of the IU School of Medicine and vice president for university clinical affairs at IU. "It also will provide a fertile ground for future physicians to learn in an advanced, collaborative environment."

The 138,000-square-foot IU Neurosciences Research Building will adjoin the ambulatory care and imaging center of the IU Health Neuroscience Center, which is nearing completion at 270,000 square feet. The first structure, designed by Indianapolis-based BSA LifeStructures, will make flexible research space available to interdisciplinary research teams with a disease focus, rather than assigning space according to traditional academic departments. Together the facilities will create a hub of expertise in neurosciences for researchers, doctors, patients and future physicians in training.

In addition to McRobbie and Daniels, ceremony speakers included Nicholas M. Barbaro, M.D., Betsey Barton Professor of Neurological Surgery and medical director of the IU Health Neurosciences Center; Charles R. Bantz, Ph.D., chancellor of IUPUI; and Daniel F. Evans Jr., president and CEO of IU Health. IU Trustees MaryEllen Bishop, William Cast, Bruce Cole, Philip Eskew Jr. and Cora Griffin were among members of the platform party.

During the ceremony, McRobbie also bestowed an honorary Doctor of Science degree upon Ferid Murad, M.D., Ph.D., an Indiana native who was awarded the Nobel Prize for Physiology or Medicine in 1998.

The cost of the neurosciences research building’s construction is $52 million, including $35 million in funding from the state of Indiana, with the remainder from IU and IU School of Medicine.

For more information, visit the IUSM Newsroom.


Arrow White Coat Ceremony to welcome school’s largest incoming class

The largest first-year IU School of Medicine class will begin classes this month, but first the 335 men and women will participate Saturday, Aug. 11, in a traditional ceremony marking the beginning of their professional lives as physicians.

The White Coat Ceremony will begin at 1 p.m. at the Murat Theatre at Old National Centre, 502 N. New Jersey St., Indianapolis.

"The White Coat Ceremony represents the start of a journey into medical school and the profession in general; graduation four years later represents successful completion of the medical school portion of that journey," said D. Craig Brater, M.D., dean of the IU School of Medicine and vice president for university clinical affairs at IU. "The highlight of both is reciting the Oath of Hippocrates where our students pledge to put their patients’ needs above all else. We are always excited to welcome a new group of talented young people who are willing to make this pledge and wear its symbol, the white coat. It bolsters our confidence that the future of medicine is in good hands."

Danyal Fer, a second-year medical student and president of the IU School of Medicine Class of 2015, said having the white coat placed upon one’s shoulders symbolizes the first step in a long journey towards the knowledge and responsibility that comes with being a physician.

"There are multiple rites of passage that one must go through in the pursuit of a career in medicine," he said. “I view the White Coat Ceremony as an individual's commitment — in front of their class and loved ones — to their personal belief that they are both capable and willing to pursue a career in medicine."

Fer also reached out a hand to first-year students, and urged them to not be intimidated by older classmates.

"Everyone’s in the same boat and under the same pressure," he said. "Don’t be afraid to go to other students with your questions and to work together with confidence."

Members of the Class of 2016 will be presented with their first white physician’s coats by IU School of Medicine faculty. Keynote speaker Stephen P. Bogdewic, Ph.D., will discuss “Our Stories, Our Lives.” Dr. Bogdewic is the executive associate dean for the Office of Faculty Affairs and Professional Development, George W. Copeland Professor of Family Medicine and associate chair of family medicine.

For more information, visit the IUSM Newsroom.


Arrow Search committee formed to find new IUSM dean

IU has initiated a national search for the next dean of the School of Medicine and vice president for university clinical affairs.

The next dean will succeed D. Craig Brater, M.D., who announced his retirement effective June 30, 2013, after 27 years of service to the IU School of Medicine, serving as dean since July 1, 2000. Dr. Brater also holds the title of Walter J. Daly Professor at the School of Medicine and is vice president for university clinical affairs at IU.

“Craig Brater has done a superb job leading the IU School of Medicine for the past 12 years and working in close partnership with IU Health and our other clinical partners," IU President Michael A. McRobbie said. "He has effectively and skillfully positioned the school as a research and clinical leader, and to meet the demands of an increasingly challenging and dynamic health care industry. I am confident the search committee members will be able to identify exceptional health care leaders who can build on the school’s record of academic success and innovation, and I greatly appreciate their commitment to IU and the School of Medicine.”

John Williams, dean of the IU School of Dentistry, will chair the search committee, which also includes faculty and staff representatives within the School of Medicine and the university, the president of the Medical Student Council and deans of the IU Schools of Science and Nursing, as well as leadership from the Indianapolis health care community including IU Health, Wishard Health Services and Richard L. Roudebush Veterans Affairs Medical Center.

An external advisory committee also is being formed to work with the search committee in identifying finalists. This will be chaired by Charles Schalliol, JD, counsel with Faegre, Baker & Daniels, who was the first president and CEO of Biocrossroads and was a former director of the state Office of Management and Budget.

An executive search firm will be selected to work with the committee to identify and screen prospective candidates, with the committee being responsible for recommending a group of finalists to McRobbie and to IUPUI Chancellor and IU Executive Vice President Charles Bantz for consideration. The new dean is expected to be in place by the beginning of the 2013-14 academic year.

For more information, visit the IUSM Newsroom.


Faculty News

Arrow Kubek earns $3 million from Army anti-suicide initiative

Michael J. Kubek, Ph.D., associate professor of anatomy and cell biology and of neurobiology, was recently awarded a $3 million research grant from the U.S. Army to develop a nasal spray that provides a quick antidote to suicidal thoughts among soldiers.

The Army-funded research collaboration on suicidal ideation is the latest development in more than three decades of work with thyrotropin-releasing hormone, or TRH, a neuro-chemical with anti-depressant and anti-suicidal properties.

“These deaths are troubling and tragic,” said Dr. Kubek, who helped discover the hormone under investigation. “Today’s commonly used anti-depressants can take weeks to have an effect and carry a black box warning label for suicidal ideation in young adults. We aim to develop a quick-acting, easy-to-use, non-invasive system that delivers a compound that’s been shown to reduce suicidal thoughts.”

The military’s interest in TRH developed from a meeting between Dr. Kubek and Navy physician Capt. Neal Naito, who served as the Navy’s director of public health before his retirement in October 2011. Dr. Naito was interested in new treatment approaches for traumatic brain injury, post-traumatic stress disorder and suicide.

Since TRH cannot easily cross the “blood-brain barrier” the body uses to protect the brain, Dr. Kubek and colleagues will develop an intranasal nanoparticle drug delivery system by which TRH or other neuropeptides could be introduced into the nasal cavity, where olfactory neurons can collect particles directly. The neuropeptides would be incorporated into biodegradable nanoparticles that dissolve at a controlled rate designed to deliver appropriate doses of the drug to the brain over time.

Abraham J. Domb, Ph.D., professor of pharmacology at Hebrew University in Jerusalem, will lead development on an optimum nanoparticle-neuropeptide combination designed to deliver the drug effectively. Clinical trials, which are expected to begin in the second year of the grant, will be directed by IU psychiatry professors Alan Breier, M.D., and Andrew Goddard, M.D., at the Indiana Clinical and Translational Sciences Institute Clinical Research Center at IU Health University Hospital.

The three-year grant is an Applied Research and Advanced Technology Development Award, part of the Department of Defense's Defense Medical Research and Development Program, funded by the Congressionally Directed Medical Research Program.

For more information, visit IUSM Newsroom.


IU Health News

Arrow IU Health provides patients ACO program information

On July 27, more than 14,400 IU Health patients with Medicare received a letter informing them that IU Health has been selected to participate in the Medicare Shared Savings (Accountable Care Organization) program.

The IU Health ACO was established on July 1. The ACO program, administered by the Center for Medicare and Medicaid Services, was established under the Affordable Care Act in 2010. Participating in the Medicare Shared Savings program significantly increases the number of patients for whom IU Health and IU Health Physicians will now be accountable for clinical and financial outcomes.

Specific benefits include the use of patient-centered medical home model and shared savings opportunities in primary care; a reduction in clinically unnecessary variations in the inpatient and acute care environments; ensuring the appropriate use of imaging, generic medication and outpatient surgical procedures; an emphasize on disease management, geriatric services and palliative and hospice care as needed; and a “patients as partners” philosophy.

Hospitals and providers participating in the IU Health ACO include IU Health Methodist, University, North, West and Saxony hospitals, IU Health Physicians, IU School of Medicine Faculty Physicians, Methodist Sports Medicine and HealthNet. The IU Health ACO is expected to further expand to include other physicians and IU Health hospitals in the future.

The information sent to patients provides general information on ACOs, explains that patients can still select their doctor and hospital, and contains details about controlling certain personal health information that the Center for Medicare and Medicaid Services will start sending to IU Health on Aug. 26. The letter also states that information about alcohol or drug treatment will not be shared without express patient permission. Patients may request that no information at all be shared by submitting a physical form (included in the letter), submitting an online form or calling 800-MEDICARE.

Patients who received this letter are likely to turn to their physician for more information. Tips on communicating this change with patients can be obtained from IU Health Physicians. These tips emphasize that the IU Health ACO does not affect Medicare benefits and no actions are required on the part of the patient. The physician, not the patient, is considered the participant in the ACO. They also note the ACO program will reduce paperwork for patients. To request ACO communication tips, contact Doyia Turner at

More information for patients and physicians about the ACO program is available online. To review this information, including the letter and forms sent to IU Health patients, visit the IU Health ACO Frequently Asked Questions.


Events & Lectures

Arrow First Indiana CTSI Distinguished Speaker — Aug. 14

Kenneth Kaitin, Ph.D., will present "Translational Science: The Evolving Landscape for Biomedical Innovation," from noon to 1 p.m. Tuesday, Aug. 14, in the VanNuys Medical Sciences Building, Room 326.

Dr. Kaitlin, director and research professor at the Tufts Center for the Study of Drug Development at Tufts University, is the first speaker in the Indiana Clinical and Translational Sciences Institute Distinguished Speaker Series.

This event is sponsored by the Indiana CTSI and hosted by Michael Sturek, M.D., chair of cellular and integrative physiology.


Arrow Kobayashi to present medical and molecular genetics seminar

Junya Kobayashi, Ph.D., associate professor of genome dynamics at the Radiation Biology Center at Kyoto University, Japan, from noon to 1 p.m. Friday, Aug. 17, in Walther Hall (R3), Room 303-305.

Dr. Kobayashi will present “Emerging roles of NBS1 in DNA damage-induced chromatin remodeling and translesion DNA synthesis.”

This seminar is presented by the Department of Medical and Molecular Genetics Seminar and hosted by Hiromi Tanaka, Ph.D., assistant professor of medical and molecular genetics.


Arrow Final summer class on EndNote X5 — Aug. 23

The last course from Ruth Lilly Medical Library on EndNote X5 will be from 1 to 2:30 p.m. Thursday, Aug. 23, in the IUSM Library, Room 227.

This class will provide an overview on how to use this bibliographic software program in the medical sciences.

For more information, contact Sherry Kieper, EndNote coordinator, at


Arrow Glick Eye Institute announces speaker's lecture topic

Ram H. Nagaraj, Ph.D., will present "Inflammatory cytokines and heat shock proteins in eye diseases" at Ophthalmology Grand Rounds from 7:30 to 8:30 a.m. Wednesday, Aug. 29, at the Eugene and Marilyn Glick Eye Institute's Spitzberg Hall.

Dr. Nagaraj is the Carl F. Asseff, M.D., professor of ophthalmology and visual sciences at Case Western Reserve University School of Medicine.

Dr. Nagaraj’s Case Western Reserve laboratory investigates two major complications of the eye: cataract and diabetic retinopathy.


Arrow Expert to discuss patient-centered outcomes

Robin Newhouse, Ph.D., RN, chair and professor of organizational systems and adult health in the School of Nursing at the University of Maryland, will present "Patient Centered Outcomes Research Institute: Introduction, Initiatives and Implications" from 9 to 11 a.m. Thursday, Aug. 30, in the Health Information and Transitional Sciences (HITS) Building, Room 1110. The lecture will be followed by a question-and-answer session from 11 to 11:30 a.m. Breakfast will be served at 8:30 a.m.

Dr. Newhouse was appointed to the Methodology Committee of the Patient-Centered Outcomes Research Institute by the comptroller general of the U.S. Government Accountability Office in 2011. She is also a member of the American Nurses Credentialing Center’s Research Council and chair of the Research and Scholarship Advisory Council for Sigma Theta Tau International.

In addition, Dr. Newhouse will present a lecture at the Fourth Annual Indiana Clinical and Translational Sciences Institute Meeting on Friday, Aug. 31, at the University Place Conference Center and Hotel. To register, visit the Indiana CTSI.

The Aug. 30 lecture is sponsored by the IU School of Nursing. To register, contact


News to Use

Arrow Scope submission deadline moved to Wednesdays

A reminder that this is the last week that Scope, the official internal e-newsletter of the IU School of Medicine, will publish on Fridays.

Scope will publish on Thursdays starting Aug. 16. The move to mid-week aims to reach more readers when they are available and ensure important medical school news reaches as many IUSM faculty, staff, students, residents and fellows as possible.

The new submission deadline for Scope items will be 8:30 a.m. Wednesday. Submissions with photos are encouraged for use on the IUSM homepage or social media channels. Submissions also may be considered for promotion on MEDTV, the IUSM digital signage system.

Tips about news, events and other activities of interest to the medical school community may be sent to Submissions from the medical school’s regional campuses are especially encouraged.

For more information, contact Kevin Fryling, communications specialist and editor of Scope, at


Arrow Indiana State Medical Association assists students, physicians

The Indiana State Medical Association has provided up to $150,000 annually in scholarships for IUSM students since 1952. Since 2000, ISMA has also paid half tuition for six medical students.

The Medical Student Section of the ISMA and American Medical Association encourages IU School of Medicine faculty members to seriously consider membership in the ISMA. Academic physicians are significantly underrepresented in organized medicine although every physician in Indiana benefits from activities financially supported by ISMA members.

The many resources and achievements of the ISMA include:

  • In 2011-12, ISMA helped negotiate a 10.2 percent decrease in the surcharge all physicians pay to the Indiana Patient’s Compensation Fund.
  • ISMA is the only physician membership organization that regularly defends malpractice law. A case now threatening the law’s damages cap could result in unlimited liability for all Indiana physicians.
  • In the General Assembly, ISMA has a daily presence to safeguard patients and physicians against harmful legislation and advance bills advantageous to medicine, including funding for the IU School of Medicine expansion.
  • ISMA’s Commission on Medical Education is the state’s only accrediting body for entities seeking to present CME for physicians.
  • ISMA is helping to plan the Indiana insurance exchange, as mandated by health care reform.

To learn more about ISMA and find an application, visit the ISMA website.


Arrow Register for lunchtime yoga sessions

Human Resources Administration Work/Life, the Student Wellness Coalition and Campus Recreation will offer two levels of lunchtime yoga classes this fall.

Classes will be from 12:05 to 12:45 p.m. in the IUPUI Campus Center (with a few exceptions) starting Aug. 20. Level I classes will be offered Mondays and Thursdays and Level II classes will be offered Tuesdays and Wednesdays.

To participate, faculty, staff and students must submit a registration form and pay the semester recreation fee. Cost is $83 for faculty and staff, and $15 for students.

For more information, visit the IUPUI HRA Website or call 317-274-5466.


Arrow Healthy IU Wellness Screenings

To encourage employees to have healthier lifestyles, IU is offering free health screenings and a $100 incentive (before tax) to full-time academic and staff employees. (Per IRS rules, the $100 incentive is paid as supplemental pay and is taxed at a higher rate than normal wages.) This program is independent of the health benefit plan.

IUPUI Health Services and IU Bloomington Health Center began providing health screenings with informational feedback for employees in August. Each month, eligible employees on the IUPUI and IUB campuses will receive an e-mail from Healthy IU inviting them to schedule an appointment. The alphabetical process will continue throughout the year. Regional campuses will have on-site screenings at least twice per year. For more details visit the Health Screening Frequently Asked Questions

Screenings for IUPUI full-time employees and spouses/same-sex domestic partners may be done at IUPUI Health Services or at your own health care provider’s office. IUPUI Health Services appointments will be scheduled from 7:30 to 9:45 a.m. Monday through Friday.

For more information, visit the Healthy IU website or contact Lee Bernard of IUPUI Student Health Services at


Arrow This week on 'Sound Medicine'

This week on "Sound Medicine," Mark Ryan, Pharm.D., director of the Louisiana Poison Control Center, will discuss the danger of synthetic drugs, including “bath salts,” which continue to be sold at many gas stations across the country and were originally suspected as being behind the vicious face-eating attack in Miami this year. Other topics on this week’s show include investigations into the reason several popular prescription drugs have been pulled from the market, how stem cells can revolutionize cancer treatment and what’s behind the increase in cancer survival rates.

"Sound Medicine," an award-winning radio program that covers controversial ethics topics, breakthrough research studies and the day-to-day application of recent advancements in medicine, is co-produced by IUSM and WFYI Public Radio and underwritten by IU Health Physicians and IUPUI. The program next airs at 2 p.m. Sunday, Aug. 12, on WFYI 90.1 FM, and is also available via podcast and Stitcher Radio for mobile phones and iPads. Reports on Primary Health Care topics are sponsored by Wishard Health Services.

For more information on this week’s show, visit the IUSM Newsroom or listen online.



Arrow Leadership in Academic Medicine Program — applications due Aug. 17

The Leadership in Academic Medicine Program, a year-long junior faculty development program for IUSM faculty, is accepting applications for the 2012-2013 academic year. Faculty members in years two and three of appointment are encouraged to apply by Friday, Aug. 17.

LAMP seminars introduce participants to the fundamentals of career planning, self-management and leadership skills. The program provides faculty the tools needed to accomplish their primary career goals and aspirations.

For more information, visit the Office of Faculty Affairs and Professional Development website or contact


Arrow IUSM internal grant applications — due Sept. 4

The application deadline for the following IUSM internal grant programs is 5 p.m. Tuesday, Sept. 4

  • Biomedical Research Grant
  • Research Enhancement Grant

For application forms and further information visit the Office of Operations website.


Arrow EMPOWER Grant Program seeks applications

The Enhanced Mentoring Program with Opportunities for Ways to Excel in Research is seeking applications. EMPOWER supports IUPUI faculty from historically underrepresented or excluded populations in their discipline or area of scholarship and who have been historically denied admission to higher education or that discipline. It aims to help such faculty become successful in sponsored research and scholarly activity and achieve significant professional growth and advancement.

The program sustains mentorship opportunities through the EMPOWER Grant Program, support of their achievement of excellence in research and scholarly activity, and the optimal attainment of academic career goals and objectives.

The application deadline is Wednesday, Sept. 5. For more information, see the grant guidelines and application forms.


Arrow McGovern Compleat Physician Award

Nominations are open for the John P. McGovern Compleat Physician Award to recognize a physician whose career has been founded on the Oslerian ideals of medical excellence, humane and ethical care, commitment to medical humanities and writing, research, and harmony between the academician and medical practitioner.

This award, established in 1993, is presented annually by the Houston Academy of Medicine in collaboration with the Harris County Medical Society

Nominations are due Friday, Nov. 2. For more information, see the online application or email Nuria Morral, Ph.D., at


Grants & Funding

Arrow Research Funding Update

The IU Office of the Vice Provost for Research and the Office of the Vice Chancellor for Research offer weekly digests containing information about funding opportunities including those that limit the number of allowable pre-proposal or proposal submissions.

Funding opportunity categories include the sciences, limited submissions, technology and multidisciplinary:

To subscribe to these updates by email, visit this page.



Arrow Fitzgerald named Distinguished Hoosier

Joseph Fitzgerald, M.D., professor of clinical pediatrics, IU School of Medicine, has been named the recipient of the Distinguished Hoosier Award by Indiana Gov. Mitch Daniels.

The Distinguished Hoosier Award is among the highest honors awarded by the governor’s office to Indiana residents. Among other things, it identifies individuals who have contributed significantly to the state and its people, and who bring recognition, administration and respect to the state through their character and accomplishments.

Dr. Fitzgerald, who was nominated by his colleagues for his years of service to the profession, is a specialist in the field of pediatric gastroenterology, hepatology and nutrition and founder of the division of pediatric gastroenterology at Riley Hospital for Children at IU Health, which was established more than 40 years ago.

"Dr. Fitzgerald has been an inspiring mentor and leader," said Jean Molleston, M.D., professor of clinical pediatrics and medicine and section director of the pediatric gastroenterology division at Riley Hospital. "He has influenced pediatricians and pediatric gastroenterologists throughout the country."

Over his career spanning multiple decades, Dr. Fitzgerald has cared for thousands of children, assuaged their parents and families, and trained the majority of pediatric gastroenterologists currently practicing in the state of Indiana. As the sole pediatric gastroenterologist in Indiana for many years, he has even earned the nickname “GI Joe.”

“He's like a grandfather to us," said Molly Bozic, M.D., assistant professor of clinical pediatrics, who recently became the newest member the division of pediatric gastroenterology trained by Dr. Fitzgerald.


 At Your Fingertips 

Arrow Continuing Medical Education

The Continuing Medical Education office launched a new and improved website at In addition to online registration and listings of grand rounds, conferences and courses, the site provides in-depth tools and information for presenters and program developers. Included are forms, tips, links, contacts, maps and other useful resources to make it easier to participate in CME events, prepare a presentation or plan an event.


Arrow Resources

Want to find a room that has a Polycom hook-up? Need official IUSM templates for your PowerPoint presentation or poster about a guest lecturer? Check out the new “Resources” page on the IUSM web site. This section is accessible from the left-hand side of the school’s home page at

If you have suggestions of other resources that would be beneficial and could be added to this list, contact the Office of Public and Media Relations at



The Office of Public and Media Relations manages the MEDTV screens on the medical school campus. This closed-circuit TV system, part of the IUPUI network, presents an opportunity for faculty, staff and students to communicate events and information of interest. It also serves as a source for broadcasting emergency information on campus.

The MedTVs are in public areas of the HITS building, the VanNuys Medical Science Building atrium and corridor/lounge, the Daly Student Center, Fesler Hall, Gatch Hall (formerly Clinical Building), Research II (R2), Walther Hall (R3) and the Cancer Research Institute (R4).

Announcements from departments and offices are welcome. To display your department or office announcement on MedTV, read the MedTV guidelines and find our online submission form at

For more information, call 317-274-7722.


Arrow Scope submission guidelines

Scope wants your news items.

The deadline for submission is 8:30 a.m. Wednesdays. Scope is published electronically and sent to faculty, staff, students and residents on Thursdays, except on holiday weekends. Photos are encouraged with submissions and also may be used on the IUSM homepage or social media channels.

There are three easy ways to submit story ideas or information to Scope:

  • E-mail the information to
  • Mail the information to Kevin Fryling, IU Communications, 251 N. Illinois St., North Tower, Suite 300, Indianapolis, IN 46204 (Campus mail; no postage required)
  • Fax your information to 317-278-8722

Contributions submitted by e-mail should be forwarded in 12-point, plain text-format. Word document attachments in lieu of fliers are encouraged.

In the interest of accuracy, please do NOT use:

  • Acronyms
  • Abbreviations
  • Campus building codes (use full, proper name of building and include the room number)
  • Dr. as a preface before names (designate M.D. or Ph.D.)
  • For more info, see the Scope Style Guide (PDF)

To keep the electronic version of Scope as streamlined as possible, only seminars and lectures of general or multidisciplinary interest will be included.