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IUSM Scope



July 27, 2012
Volume 16 Number 29 • Indianapolis, Indiana

Topics this issue:

Above the Fold

Arrow Medicine and optometry to create exchange program with India

The IU schools of medicine and optometry are creating a new academic exchange program, the Indo-U.S. Exchange Program for Optometry and Ophthalmology, with four eye institutes and hospitals in India.

This two-year pilot program will provide IU School of Optometry residents the opportunity to enhance postgraduate training with a month-long trip to eye institutes and hospitals in Chennai, Mumbai and Hyderabad, India. In turn, eye care professionals from participating institutions in India will spend one month in the U.S. visiting the Eugene and Marilyn Glick Eye Institute at the IU School of Medicine and IU School of Optometry in Bloomington.

Eight eye care professionals from India and eight IU optometry residents will participate in the exchange program during the first two years, at which point additional optometry and ophthalmology institutions within the U.S. will be invited to join the IU program.

Participating institutions in India are Sankara Nethralaya, a nonprofit eye institute in Chennai; LV Prasad Eye Institute in Hyderabad; and Hinduja Hospital and Shroff Eye Hospital, both in Mumbai. Principal investigators for the program are Louis Cantor, director of the Glick Eye Institute, professor of ophthalmology and Jay C. and Lucile L. Kahn Professor of Glaucoma Research and Education at the IU School of Medicine; Jeffrey Perotti, O.D., clinical assistant professor and director of community outreach at the IU School of Optometry; and P. Sarita Soni, O.D., professor of optometry and vice provost for research at IU Bloomington.

IU and its Indian partners will provide about 70 percent of the estimated $410,000 cost of the two-year pilot program, with the Indo-U.S. Science and Technology Forum providing the remaining support.

For more information, visit the IU Newsroom.

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Arrow IU School of Medicine researchers earn signature center funds

Kody Varahramyan, Ph.D. vice chancellor for research at IUPUI, has announced the recipients of the 2012 IUPUI Signature Center Initiative Awards, including four faculty members from the IU School of Medicine.

The funded centers are the Center for Pediatric Obesity and Diabetes Prevention Research, co-directed by Aaron Carroll, M.D., associate professor of pediatrics, and David Marrero, Ph.D., J. O. Ritchey Professor of Medicine, and the Center for Human Papilloma Virus Research, co-directed by Gregory D. Zimet, Ph.D., professor of pediatrics and clinical psychology, and Dennis J. Fortenberry, M.D., professor of pediatrics and medicine. Each will receive $300,000 over the next three years, after which they will undergo a rigorous review process to determine eligibility for formal Signature Center designation.

The mission of the Center for Pediatric Obesity and Diabetes Prevention Research is the performance and translation of research in obesity and diabetes prevention among children and adolescents. The center is dedicated to advancing the health of vulnerable populations through internationally recognized obesity and diabetes prevention research focusing on mechanisms of progression from obesity to Type 2 diabetes, defining best practices for obesity/diabetes prevention among youth, and cost-effective translation of the research to the community.

The mission of the Center for HPV Research is to improve understanding of human papillomavirus transmission and infection, and prevention of HPV infection and its consequences. The center brings together researchers from multiple health and life sciences disciplines. These researchers are engaged in the realization of multiple collaborative projects including transmission and prevention of HPV infection.

The third center funded under the 2012 IUPUI Signature Center Initiative Award is the Center for Civic Literacy, co-directed by Sheila Kennedy, J.D., professor of public and environmental affairs at the School of Physical Education, and Anthony Cox, MBA, Ph.D., professor of marketing and Chancellor’s Faculty Fellow at the IU Kelley School of Business at Indianapolis.

The Signature Centers Initiative was begun in 2006 by Uday Sukhatme, former executive vice chancellor and dean of the faculties at IUPUI, to create nationally and internationally recognized research centers that are uniquely identifiable with IUPUI.

For more information, visit Inside IUPUI.

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Arrow Indiana CTSI awards partnership grants

The Indiana Clinical and Translational Sciences Institute and West Virginia Clinical and Translational Science Institute have granted $100,000 to support cross-institutional research projects focused on developing treatments for alcoholism and dental anxiety.

Nicholas J. Grahame, Ph.D., associate professor of psychology at Indiana University Purdue University Indianapolis, and Han-ting (Hunter) Zhang, M.D., Ph.D., assistant professor of behavioral medicine and psychiatry and physiology and pharmacology at West Virginia University, will receive $50,000 to support their investigation into an enzyme with potential as a drug target for reducing “alcohol-seeking behavior” in problem drinkers.

Andrew W. Goddard, M.D., professor of psychiatry and professor of radiology and imaging sciences at the IU School of Medicine, and Daniel W. McNeil, Ph.D., Eberly Professor of Public Service and psychology and clinical processor of dental practice and rural health at West Virginia University, will receive $50,000 to support the design of a clinical trial focused on using a skin patch designed to deliver anti-anxiety mediation in combination with exposure therapy to reduce or eliminate the fear experienced by some patients when visiting the dentist.

“The Indiana CTSI is pleased to work with our partners at the West Virginia CTSI to help usher these two promising projects into the next phase of their development,” said Anantha Shekhar, M.D., Ph.D., director of the Indiana CTSI, associate dean for translational research and Raymond E. Houk Professor of Psychiatry at the IU School of Medicine. “Alcoholism and anxiety, including the fears which prevent some from accessing adequate dental care, are serious problems that require novel solutions.”

These awards are the first granted through a new joint pilot funding program that supports research to address health and health care issues at the Indiana CTSI and West Virginia CTSI. Both institutes are among the 60 centers established by the Clinical and Translational Science Award of the National Institutes of Health to accelerate research that translates laboratory research into new treatments and therapies.

For more information, visit the Indiana CTSI.

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Student Showcase

Arrow Middle school education programs close with ceremony

The Middle School Academy of Science and Health Sciences (MASH) and Brain Link programs, sponsored by the IUSM Office of Faculty Affairs and Professional Development, Division of Diversity Affairs, held their closing ceremony at 10 a.m. Friday, July 27, in the Emerson Hall auditorium.

The celebration culminated three weeks of rigorous classroom and laboratory experiences provided by certified teachers, aided by IU medical and graduate student teacher assistants, designed to creatively engage the more than 175 fifth- through eighth-grade participants in meaningful, hands-on science education.

Summer learning activities included hands-on dissections, mathematics, science, and language arts each morning, with experiments in general science, computer literacy training, introductory laboratory dentistry in the afternoon. Other activities included a book club, swimming and additional recreational programming. The MASH and Brain Link programs are designed to challenge students emerging intellect, ignite curiosity and whet appetites for the next “learning plateau.”

More than 20 school districts were represented in this year’s programs, including the Indianapolis Public Schools, Decatur Township, Queen Anne’s School, Christ the King School, Oaks Academy, Hoosier Academy, Park Tutor Elementary, Heritage Christian, Indianapolis Lighthouse, Pike Township, Washington Township, Avon Schools, Brownsburg Schools, Sycamore School, Charles Tinley, St. Monica School, St. Lawrence Catholic School, St. Richards, St. Joan of Arc, Imagine Academy East/West, Indiana Math and Science Academy (both locations), St. Simon, Fisher Schools and West Field Schools. 

Early identification initiatives such as the MASH and Brain Link programs, a part of Diversity Affairs’ Diversity Outreach Comprehensive Science (DOCS) Initiative, have been successful in attracting elementary and middle school students, particularly those of color, to careers in the life and health sciences.  All students were competitively selected and attended free of charge.

For more information, visit the DOCS Initiative Webpage.

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Arrow Summer lab internship program marks another year

IUSM students led small group discussions about careers in science and medicine with local high school and undergraduate students Tuesday, July 24, in the Health Information and Translational Sciences (HITS) Building.

The discussions took place at a lunch to celebrate another year of the Indiana CTSI summer internship program, a partnership with the IUSM Student Research Program in Academic Medicine, IUPUI Center for Research and Learning and Indianapolis Project SEED, which assigns medical, undergraduate and high school students as lab assistants with Indiana CTSI-affiliated research scientists. Anantha Shekhar, M.D., Ph.D., director of the Indiana CTSI, also addressed students during the event, which was attended by the many faculty mentors, administrators and other volunteers integral to the success of the annual program.

The Indiana CTSI summer internship program provides funds each year for approximately 25 medical, eight undergraduate and 20 high school students to participate in summer internships. Participants include high school students from across Central Indiana, undergraduate students from Indiana and Notre Dame universities and medical students from the IU School of Medicine.

A poster session and closing ceremony with participants from Indianapolis Project SEED was also held from 4 to 6 p.m. Thursday, July 26, in the VanNuys Medical Science Building auditorium.

To see photos from Tuesday’s event, visit the IUSM Facebook page or the Indianapolis Project SEED photo album.

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Faculty News

Arrow Kline to serve as vice chair of research

Jeffrey A. Kline, M.D., has been appointed vice chair of research in emergency medicine and professor of cellular and integrative physiology at the IU School of Medicine.

Dr. Kline, former interim chair of emergency medicine and medical director of research at the Carolinas Healthcare System in Charlotte, N.C., is known internationally for his clinical and translational research on pulmonary embolism and for creating start-up companies developing medical diagnostic devices. He is a past president of the Society for Academic Emergency Medicine.

Dr. Kline will direct emergency care research conducted at IU-affiliated hospitals and develop a multidisciplinary thrombosis research and treatment center in Indianapolis. He also is director of the emergency care research fellowship. His appointment is effective Aug. 1.

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Arrow New fellowship directors appointed

The Office of Graduate Medical Education has appointed two new directors for its fellowship programs in infectious diseases and pediatric urology.

Diane Janowicz, M.D., assistant professor of clinical medicine, has been named program director for the Internal Medicine-Infectious Disease Fellowship. This ACGME-accredited fellowship has educated specialists in the medical subspecialty of infectious disease since 1987.

Rosalia Misseri, M.D., assistant professor of urology, has been named the program director for the Pediatric Urology Fellowship.  This ACGME-accredited fellowship has educated specialists in the medical subspecialty of Pediatric Urology since 1998.

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Events & Lectures

Arrow Glick Eye Institute expands vision symposium

The third annual Vision Symposium conducted by the IU Department of Ophthalmology at the Eugene and Marilyn Glick Eye Institute will expand to two days this year and feature a half day of clinical updates in addition to a full day of research presentations.

Research will be the focus of the program on Friday, Nov. 2; clinical updates will be provided in a half-day program on Saturday, Nov. 3. All programs will be in Spitzberg Hall at the Glick Eye Institute.

Featured speakers for the 2012 research program include

  • Louis Pasquale, M.D., director of glaucoma service and telemedicine at Massachusetts Eye and Ear in Boston, will present “The reverse engineering cycle of discovery in glaucoma.”
  • Jost Jonas, M.D., a faculty member in clinical medicine at Mannheim-Heidelberg, Mannheim, Germany, will present “Pathogenic implications from the morphology of the glaucomatous optic nerve head.”
  • Einar Stefansson, M.D., a retina faculty at the University of Iceland, Reykjavik, Iceland, will present “Retinal oximetry in health and disease.”

Abstracts are sought for additional speakers for the research program. Abstract submissions are due by 5 p.m. Monday, Aug. 27; selections will be announced by Sept. 14.

The keynote speaker for the clinical program will be Wallace L.M. Alward, M.D., a glaucoma specialist at the University of Iowa. Ophthalmology faculty and area physicians also will present Saturday on topics such as diabetic retinopathy, age-related macular degeneration, cornea disease to glaucoma. A tentative agenda is online.

Registration is $50 for M.D./Ph.D. participants; $35 for postdoctoral participants; and $25 for residents and students. Meals and conference materials are included. Continuing medical education credits are available.

For more information as it becomes available, visit the vision symposium website.

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Arrow Free children’s health fair — July 28

The IU School of Medicine Pediatric Student Interest Group will co-sponsor a free children’s health fair from 8 a.m. to noon Saturday, July 28, at the Blackburn Health Center, 2700 Dr. Martin Luther King Jr. St., in Indianapolis.

The Randall S. Smith Jr. Children’s Health Fair will feature health screenings, sports physicals, immunizations and children’s games. Parents are asked to bring their children’s immunization records. Sports physicals will be for junior high and high school students. A bone marrow registration and education booth will also be part of the day’s activities.

Wishard staff members will be available to provide nutrition education tips and representatives from Brown Mackie College to answer questions and hand out college information. Children’s games, food and music will also be part of the day’s activities.  

Additional event sponsors include Wishard Health Services, Eskenazi Medical Group, MDwise, St. Margaret’s Hospital Guild, Brown Mackie College and Peace of Cake Party and Event Services.  

For more information, call 317-931-4303.

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Arrow Interactive theater performance to begin academic year

An award-winning theater group will present an interactive theater performance for faculty and students from 4:30 to 7:30 p.m. Thursday, August 9, in the IUSM Library, Room 317.

The Case Study: An Interactive Performance to Improve Medical Education includes a facilitated discussion on strategies for addressing controversial topics in a productive way and an opportunity to collaborate to brainstorm methods of dealing with unexpected conflict. 

Dinner will be provided from 4:30 to 5:30 p.m. and the performance will begin at 5:45 p.m.

This performance is open to the entire IUSM community and is sponsored by the IU School of Medicine Office of Faculty Affairs and Professional Development and Office of Educational Affairs. 

To register, visit the OFAPD website.

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Arrow Scientific Writing from the Reader’s Perspective

George Gopen, Ph.D., J.D., will present a one-day workshop on Scientific Writing from the Reader’s Perspective” from 8 a.m. to 5 p.m. Tuesday, Sept. 11, in the Riley Outpatient Center Auditorium and Wednesday, Sept. 12, in the Lilly Auditorium, IUPUI Library.

As competition for external funding becomes more challenging, getting one’s scholarly work successfully published is more important than ever. In this workshop, Dr. Gopen, professor of rhetoric at Duke University, will share key skills needed to adapt scholarly works for any audience.

This event is sponsored by the IU School of Medicine Office of Faculty Affairs and Professional Development, the Department of Emergency Medicine, the IUPUI Office of the Vice Chancellor for Research, and the IUPUI Center for Teaching and Learning.

To sign up, visit the registration page.

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Arrow Conference to focus on public health management

The Indiana Public Health Training Center will host its second annual leadership conference, "Learn, Connect, Act and Empower: Effective Management in Public Health," on Tuesday, Aug. 7, in the IUPUI Campus Center, Room 409/450.

This professional development conference will focus on leadership, management and communication skills. Breakout topics include management ethics, conflict resolution, and confidence and privacy.

Registration is $70. For more information or to sign up, visit the registration page.

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News to Use

Arrow Student volunteers sought for medical ELS course

Student volunteers are sought for a language education program aimed at international medical professionals from 5 to 7 p.m. Tuesdays, Aug. 7 to Oct. 9, in IU Health Methodist Hospital.

Volunteers for this a 10-week course, American English for Internationals, will act as teaching assistants for the ESL instructors. They will communicate with international medical professionals and provide feedback on variations in their speech from the American English pronunciation norms. The students will contribute to the improvement in the overall quality of health care in our institution not only by helping the participants in improving their communication skills, but also by facilitating their own understanding of linguistic and cultural differences in communication styles.

Students will receive a letter of appreciation for volunteering in the program. Parking passes for Garage 1 on Senate Blvd. will be available on request.

For more information, visit the course Web page or contact 317-962-2275 or pkhurana@iupui.edu.

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Arrow IU Health launches tool for patient families and friends

IU Health has launched a new online resource to help patients, families and their friends respond in an organized and helpful way when a loved one is hospitalized.

The Strength of Friends website can be used to coordinate schedules for meals, child or pet care, errands; provide information and blog updates; share photos; and allow friends and family to post messages.

To register and create a website, a coordinator, such as a family member or friend, must complete a brief sign in process. The website contains simple instructions to help you customize a page that can best meet patients’ needs.

For more information, visit The Strength of Friends website.

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Arrow Indiana vaccination records available online

“MyVaxIndiana,” an online tool from the Indiana State Department of Health to provide state residents direct access to their immunization records, launched July 23.

Users can access their immunization record on the secure website using their date of birth and a personal identification number which must be requested from their healthcare provider or local health department in advance. Available information includes personal immunization histories and an immunization schedule from the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices. All records can be downloaded, printed or faxed from the site.

MyVaxIndiana records appear as they are maintained in the Indiana Children and Hoosiers Immunization Registry Program. MyVaxIndiana complements CHIRP, which is supported by the Centers for Disease Control and Prevention. Approximately 4 million Hoosiers have “active” records in CHIRP, which is defined as having two or more vaccines entered.

Deanna Willis, M.D., associate professor of family medicine and president of the Indiana Academy of Family Physicians, was among the speakers at an Indiana State Department of Health news conference to announce the site.

For more information, visit www.MyVaxIndiana.in.gov.

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Arrow Indiana State Fair discount tickets

Indiana State Fair tickets are now available at the Jagtag Office in the IUPUI Campus Center for $7.50 each. To order tickets, visit the JagTag website.

In addition, Indianapolis Children's Museum tickets are also available for $15.25 for adults and $11 for children and discounted Children's Museum Memberships for $125.

New vendors to accept JagTag as payment include When Eddie Met Salad, which offers a wide variety of fresh salads, sandwiches and wraps, located at 913 Indiana Ave.

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Arrow This week on 'Sound Medicine'

This week on Sound Medicine, IU dermatologist Mark Holbreich, M.D., will explore what may make Amish children significantly less susceptible to allergies and asthma. Other topics include an urban farming project in Milwaukee that produces 40 tons of fresh fruits and vegetables a year and supports tens of thousands of fish, the popularity of “juice diets,” and an interview with the author of “The First 20 Minutes: Surprising Science Reveals How We Can Exercise Better, Train Smarter, Live Longer.”

Sound Medicine, an award-winning radio program that covers controversial ethics topics, breakthrough research studies and the day-to-day application of recent advancements in medicine, is co-produced by IUSM and WFYI Public Radio and underwritten by IU Health Physicians and IUPUI. The program next airs at 2 p.m. Sunday, July 29, on WFYI 90.1 FM, and is also available via podcast and Stitcher Radio for mobile phones and iPads. Reports on Primary Health Care topics are sponsored by Wishard Health Services.

For more information on this week’s show, visit the IUSM Newsroom or listen online.

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Opportunities

Arrow IU Health grant on religion and medicine — letter of intent due Aug. 7

IU Health is seeking applications for its 2013-14 Values Fund grants in the categories of “Medical Research,” “Medical Education” and “The Integration of Religious and Spiritual Dimension in Health Care.”

A letter of intent — as well as any questions — must be submitted for the Integration of Religious and Spiritual Dimensions in Health Care by Monday, Aug. 7. Applications are due by noon Monday, Oct. 15, to the attention to Steven Ivy, Ph.D., senior vice president for Values Ethics, Social, Responsibility and Pastoral Services via Nicole Veal at 317-962-3591 or nveal@iuhealth.org.

Eligible applicants include employees of the IU Health Academic Health Center (i.e. IU Health University, Riley at IU Health, IU Health Saxony and IU Health Methodist) or those with IU Health medical staff, including physicians and health professionals with admitting privileges at the IU Health Academic Health Center.

For more information, or to apply, visit this page.

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Arrow Scholarships for foreign-born medical scientists — applications due Aug. 14

The Vilcek Foundation recognizes young, foreign-born biomedical scientists who have distinguished themselves through exceptional and innovative research at an early stage of their career.

Three winners, 38 years or younger, will be selected in 2013 to receive unrestricted cash prizes of $35,000 each. The Vilcek Prizes for Creative Promise in Biomedical Science aim to highlight the drive, talent and ingenuity of young immigrants.

The online application, along with details about the prize, the Vilcek Foundation, and its other programs and events, can be found at the Vilcek Foundation website.

Applications are due Tuesday, Aug. 14. No fee is required to apply.

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Arrow Leadership in Academic Medicine Program — applications due Aug. 17

The Leadership in Academic Medicine Program, a year-long junior faculty development program for IUSM faculty, is currently accepting applications for the 2012-2013 academic year. Faculty members in years two and three of appointment are encouraged to apply by Friday, Aug. 17.

LAMP seminars introduce participants to the fundamentals of career planning, self-management and leadership skills. The program provides faculty the tools needed to accomplish their primary career goals and aspirations.

For more information, visit the Office of Faculty Affairs and Professional Development website or contact ofapd@iupui.edu.

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Grants & Funding

Arrow Research Funding Update

The IU Office of the Vice Provost for Research and the Office of the Vice Chancellor for Research offer weekly digests containing information about funding opportunities including those that limit the number of allowable pre-proposal or proposal submissions.

Funding opportunity categories include the sciences, limited submissions, technology and multidisciplinary:

To subscribe to these updates by email, visit this page.

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Kudos

Arrow Honors

Alexander B. Niculescu III, M.D., Ph.D., associate professor of psychiatry and medical neuroscience, has been selected as one of seven New Innovator Awardees to present a talk at the Eight Annual NIH Director’s Pioneer Award Symposium from Sept. 13 to 14 in Bethesda, Md. Dr. Niculescu, who also serves as director of the Laboratory of Neurophenomics at the Institute of Psychiatric Research at the IU School of Medicine, received his award in 2010 for his work on developing blood tests for mood disorders. He was selected to speak from more than 100 similar recipient from all fields of biomedicine.

William J. Sullivan, Ph.D., associate professor of pharmacology and toxicology and microbiology and immunology, has been appointed as a member of the AIDS-Associated Opportunistic Infections and Cancer Study Section at the Center for Scientific Review at the National Institutes of Health. Study section members are selected on the basis of their demonstrated competence and achievement in their scientific discipline as evidenced by the quality of research accomplishments, publications in scientific journals, and other significant scientific activities, achievements and honors. Study sections review grant applications submitted to the NIH, make recommendations on these applications to the appropriate NIH national advisory council or board and survey the status of research in their fields of science.

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Traffic Updates

Arrow North Street Garage closures

The North Street Garage will close due to construction from July 27 to 30 and from Aug. 3 to 6 in order to complete the ground floor parking deck, entrances, and exit lanes.

On both weekends, the garage will reopen the following Monday at 5 a.m. Anyone holding a valid "NG" permit will be permitted to park in any of the surrounding surface lots during this time.

For more information, contact Parking Services at 317-274-9975.

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 At Your Fingertips 

Arrow Continuing Medical Education

The Continuing Medical Education office launched a new and improved website at cme.medicine.iu.edu. In addition to online registration and listings of grand rounds, conferences and courses, the site provides in-depth tools and information for presenters and program developers. Included are forms, tips, links, contacts, maps and other useful resources to make it easier to participate in CME events, prepare a presentation or plan an event.

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Arrow Resources

Want to find a room that has a Polycom hook-up? Need official IUSM templates for your PowerPoint presentation or poster about a guest lecturer? Check out the new “Resources” page on the IUSM web site. This section is accessible from the left-hand side of the school’s home page at medicine.iu.edu.

If you have suggestions of other resources that would be beneficial and could be added to this list, contact the Office of Public and Media Relations at medschl@iupui.edu.

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Arrow MEDTV

The Office of Public and Media Relations manages the MEDTV screens on the medical school campus. This closed-circuit TV system, part of the IUPUI network, presents an opportunity for faculty, staff and students to communicate events and information of interest. It also serves as a source for broadcasting emergency information on campus.

The MedTVs are in public areas of the HITS building, the VanNuys Medical Science Building atrium and corridor/lounge, the Daly Student Center, Fesler Hall, Gatch Hall (formerly Clinical Building), Research II (R2), Walther Hall (R3) and the Cancer Research Institute (R4).

Announcements from departments and offices are welcome. To display your department or office announcement on MedTV, read the MedTV guidelines and find our online submission form at communications.medicine.iu.edu/get-the-word-out/medtv.

For more information, call 317-274-7722.

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Arrow Scope submission guidelines

Scope wants your news items.

The deadline for submission is 8:30 a.m. Thursdays. Scope is published electronically and sent to faculty, staff, students and residents on Fridays, except on holiday weekends. Photos are encouraged with submissions and also may be used on the IUSM homepage or social media channels.

There are three easy ways to submit story ideas or information to Scope:

  • E-mail the information to scopemed@iupui.edu
  • Mail the information to Kevin Fryling, IU Communications, 251 N. Illinois St., North Tower, Suite 300, Indianapolis, IN 46204 (Campus mail; no postage required)
  • Fax your information to 317-278-8722

Contributions submitted by e-mail should be forwarded in 12-point, plain text-format. Word document attachments in lieu of fliers are encouraged.

In the interest of accuracy, please do NOT use:

  • Acronyms
  • Abbreviations
  • Campus building codes (use full, proper name of building and include the room number)
  • Dr. as a preface before names (designate M.D. or Ph.D.)
  • For more info, see the Scope Style Guide (PDF)

To keep the electronic version of Scope as streamlined as possible, only seminars and lectures of general or multidisciplinary interest will be included.

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