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IUSM Scope



July 6, 2012
Volume 16 Number 26 • Indianapolis, Indiana

Topics this issue:

Above the Fold

Arrow Bioethics panel discussion to host UK's top drug regulator

The IU Center for Bioethics will co-host a panel presentation on the “Ethical and Scientific Issues in Studying the Safety of Approved Drugs” from 3 to 4 p.m. Wednesday, July 11, at the Health Information and Translational Science (HITS) Building, Room 1110. 

Panel presenters are Sir Alasdair Breckenridge, chair of the Medicines and Healthcare Products Regulatory Agency, London, U.K.; Bruce Psaty, M.D., Ph.D., professor of medicine, epidemiology and health services and co-director of the Cardiovascular Health Research Unit at the University of Washington; and Eric Meslin, Ph.D., director of the IU Center for Bioethics and associate dean for bioethics at the IU School of Medicine. Breckenridge, Psaty and Meslin were members of the Institute of Medicine Committee on Ethical and Scientific Issues in Studying the Safety of Approved Drugs, whose recently published report is the focus of the panel.

This event is co-hosted by the IU Center for Bioethics; Indiana Clinical and Translational Sciences Institute; Regenstrief Institute; Office of the Executive Associate Dean of Research, IU School of Medicine; and the Indiana Institute for Personalized Medicine.

For more information, contact Eva Jackson at 317-278-4034 or evajacks@iupui.edu.

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Arrow IUSM scientists join research initiative on Alzheimer’s genetics

IUSM researchers will join a new national initiative to explore the genetic roots of Alzheimer’s disease by sequencing the entire genomes of more than 800 older adults. The project was announced July 1.

The Alzheimer’s Disease Neuroimaging Initiative, supported by the Brin Wojcicki Foundation and the Alzheimer’s Association, will provide a listing of all 3 billion segments of genetic code — called base pairs — in each participant’s DNA. By sequencing the entire genetic code for each of the ADNI participant, scientists will be able to dive deeper into the molecular level to find rare variations within genes that play as-yet-unknown roles in Alzheimer’s disease. 

“This is the equivalent of going from a good quality map of the Unites States to having the detailed blueprints for everything within our borders,” said Andrew Saykin, Psy.D., director of the Indiana University Center for Neuroimaging and principal investigator for the genetics core of the Alzheimer’s Disease Neuroimaging Initiative.

In addition to Dr. Saykin’s leadership, the National Cell Repository for Alzheimer's Disease at the IU School of Medicine will serve as the storage site for the DNA samples collected around the country for the initiative. The repository, directed by Tatiana Foroud, Ph.D., P. Michael Conneally Professor of Medical and Molecular Genetics, prepared the DNA samples that will be used for the new whole genome project. Dr. Foroud and Li Shen, Ph.D., computer scientist and assistant professor of radiology and imaging sciences, are co-principal investigators for the genetics core.

 “This whole genome sequencing project should give us important new insights into the origins and processes of Alzheimer’s disease, helping us develop new treatments and hopefully new preventive therapies,” said Martin Farlow, M.D., professor of neurology and associate director of the Indiana Alzheimer Disease Center. Dr. Farlow leads the IU ADNI clinical site and provides clinical services to Alzheimer’s patients at IU.

Alzheimer’s disease and other dementias are among the areas of focus of both the IU Health Neurosciences Center and the Strategic Research Initiative, two research and clinical care collaborations between the IU School of Medicine and IU Health.

For more information, visit the IUSM Newsroom.

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Arrow Mobile electronic medical record program honored

The nation's first and only program linking paramedics  to electronic health information in the field has been recognized by the prestigious Computerworld Honors Program.

The Indianapolis Emergency Medical Services Electronic Patient Care Reporting / Indiana Network for Patient Care program, a collaboration of Indianapolis EMS, INPC, Regenstrief Institute, Indiana Health Information Exchange and Medusa Medical Technologies was recently honored for providing emergency medical technicians the ability to securely access a patient’s health data in the field during a ceremony in Washington, D.C.

“Electronic medical record technology has been widely recognized for its role in improving quality of care, increasing efficiency of health care delivery, preventing medical errors and enhancing patient safety," said John T. Finnell, M.D., associate professor of emergency medicine at the IU School of Medicine and director of health informatics at the IU School of Informatics, who developed the link between electronic medical records and emergency treatment in the field. "Indianapolis is the only place in the country that is able to securely push health care data to medics in real time, which can impact the pre-hospital care provided."

Metropolitan Indianapolis is the most health wired area in the United States, with Indianapolis ambulances carrying tablet computers with secure access to patient data abstracts compiled from visits to hospital systems, along with laboratory test results and prescription information. The system enables paramedics to make decisions based extremely up-to-date information, such as the ability to compare a heart attack victim’s previous EKG to an emergency EKG administered in the field.

Computerworld Honors is the longest-running global program to honor individuals and organizations that use information technology to promote positive social, economic and educational change. 

For more information, visit the IUSM Newsroom.

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Faculty News

Arrow Hashino named Ruth C. Holton Professor of Otology

Eri Hashino, Ph.D., will be named the first holder of the Ruth C. Holton Chair in Otology effective Aug. 1, pending approval by the IU trustees. 

Dr. Hashino’s official faculty titles will be Ruth C. Holton Professor of Otology. She will also retain her position as professor of otolaryngology-head and neck surgery, professor of anatomy and cell biology, and adjunct professor of pharmacology and toxicology.

Dr. Hashino’s research focus us on using cellular and molecular biology, biochemistry, cellular electrophysiology and imaging, magnetic resonance imaging and animal models to explore the cellular mechanisms of inner ear sensory neurons.

She holds a bachelor’s in experimental psychology from Tokoya Women’s Christian University, a masters’ in neuroethology from Osaka University and a doctor in neurobiology from the Nagoya University School of Medicine in Japan. She also earned a post-doctorate degree in auditory neuroscience from the State University of New York at Buffalo, where she served as a research scientist from 1994 to 2002. She joined the IUSM faculty in 2002 as an associate professor of anatomy and cell biology and earned tenure in 2009.

The Ruth C. Holton Chair in Otology was established in 1998 by the estate of Philip F. and Ruth C. Holton in order to attract and retain the highest caliber educators who will create an environment rich in scientific inquiry to provide advancement for children and adults with otological diseases. It is the intent of the donors that the holder of the chair will be a faculty member engaged in basic or clinical otologic research and teaching.

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Arrow Eskew re-elected Indiana University trustee

Philip N. Eskew Jr., volunteer clinical professor of obstetrics and gynecology, was re-elected to a three-year term as an IU trustee on July 1.

Eskew, who earned a medical degree from the IU School of Medicine in 1970, is the retired director of physician and patient relations at St. Vincent Hospital in Indianapolis. In addition to serving as a volunteer clinical faculty at the IU School of Medicine, he is a life member of the IU Alumni Association. He is also a diplomate on the American Board of Obstetrics and Gynecology.

IU has nine trustees, three of whom are elected by alumni. Eskew, who was first elected in 2006, received 10,109 out of the 15,657 valid votes cast. Michael D. Shumate of Los Angeles received 5,548 votes.

For more information, visit the IU Newsroom.

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Student Showcase

Arrow 'Reflections' seeks creative submissions

Submissions are being accepted for the 2012 edition of “Reflections,” an annual publication by IUSM medical students that showcases the creative talents of IUSM students, faculty and staff in a way that inspires the reader.

The theme for this year is “Diversity.” The publication is accepting any and all creative media by IU students, faculty, staff and alumni.

Submission deadline is Sunday, July 15. Notifications of acceptance will be provided by Wednesday, July 25. A copy of “Reflections” will be presented to IUSM students during the 2012 White Coat Ceremony on Saturday, Aug. 11.

“Reflections” is produced by the Creative Art Therapy Student Interest Group, with additional support provided in part by the Office of Medical Education and Curricular Affairs.

To learn more about “Reflections,” or to submit work, visit the publication website. For other inquires, contact Drew Oehler at acoehler@iupui.edu.

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Events & Lectures

Arrow Microbiology and immunology seminar

Muithi M. Mwanthi, a graduate student in the Department of Microbiology and Immunology, will present a thesis defense seminar from noon to 1 p.m. Friday, July 6, in Walther Hall (R3), room 203.

Mwanthi’s presentation will be entitled “PAK-1’s regulation of eosinophil migration and implications for asthmatic inflammation.”

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Arrow IUSM Library to present course on EndNote X5

The Ruth Lilly Medical Library will offer a class on EndNote X5 from 10 to 11:30 a.m. Thursday, July 12, in the IUSM Library, Room 227.

The class will provide an overview on how to use EndNote X5 bibliographic software in the medical sciences.

For more information, contact Sherry Kieper, EndNote coordinator, at skieper@iupui.edu.

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Arrow Hoosier Healthcare Innovation Challenge — July 13

The first Hoosier Healthcare Innovation Challenge will be from 8 a.m. to 4:45 p.m. Friday, July 13, at the Informatics and Communications Technology Complex.

This event will bring together leaders from Indiana's health care, technology and entrepreneurial communities to foster cross-sector collaborations aimed at improving  patient care, reducing health care costs and continuing to establish Indiana as a premiere location for health IT innovation. Agenda items include presentations; breakout sessions, including a working session with hospital information technology experts; and a networking reception.

The Hoosier Healthcare Innovation Challenge is a TechPoint initiative presented by TechPoint's Advancing Life Sciences and Health Care Information Technology Group, Develop Indy and Ice Miller LLP. It is sponsored by CoreTech Revolution, Indiana Clinical and Translational Sciences Institute, Indiana Economic Development Corporation, Indiana Health Information Exchange, Indiana University Health, Indiana Health Information Management Systems Society, Purdue Research Park, Startup Weekend Indianapolis and St. Vincent Health.

This event is open to physicians, nurses, hospital administrators, information technology professionals and entrepreneurs. Registration is $40 (or $80 for a “team of three”) and includes seminar materials, a luncheon and the reception.

For more information, visit the Hoosier Healthcare Innovation Challenge website or email hoosierchallenge@techpoint.org.

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Arrow AAMC Professional Development Conference

The registration deadline for the Association of American Medical Colleges' 2012 Group on Faculty Affairs and Group on Diversity Inclusion Joint Professional Development Conference is Friday, July 20.

The theme of the first GFA/GDI Joint Professional Development Conference, to be held Aug. 9 to 12 at the Westin Hotel in Indianapolis, is “Creating Diverse and Inclusive Cultures: Transforming Ourselves, Our Faculty, Our Institutions."

The event will provide a forum to highlight the collaborations that occur at academic medical centers by bringing together two influential AAMC professional development groups critical to the transformation of academic medicine.

IUSM speakers will include D. Craig Brater, M.D., IUSM dean and IU vice president for clinical affairs; Maryellen E. Gusic M.D., executive associate dean for educational affairs; George Rausch Ed.D., associate dean for diversity affairs and associate professor of clinical family medicine; and Mary E. Dankoski, Ph.D., associate dean for faculty affairs and professional development and associate professor and Lester D. Bibler Scholar in Family Medicine.

Plenary sessions will focus on the subjects such as unconscious bias, inter-professional education and collaboration, talent management and transforming institutional culture. To see a complete agenda, visit the AAMC website. The registration deadline is Friday, July 20. Online registration is $655. To register, visit this page.

For more information, contact Carlos LaTorre at 202-828-0502 or clatorre@aamc.org.

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Arrow Fourth Annual Indiana CTSI Meeting

Mark your calendar: The fourth annual meeting of the Indiana Clinical and Translational Sciences Institute will be Friday, Aug. 31, at the University Place Conference Center and Hotel.

The highlight of the program will be plenary talks by leaders from the National Institutes of Health, Patient-Centered Outcomes Research Institute, Center for Medicare and Medicaid Services and elsewhere that will provide insights into how biomedical research is evolving nationally. It will also provide an opportunity to learn more about the Indiana CTSI, participate in poster presentations and breakout sessions, and meet new colleagues and collaborators.

This is a free event and is open to anyone who wants to learn more about the Indiana CTSI and its programs. A complete agenda and registration information are to be announced.

For more information, visit the Indiana CTSI HUB or contact info@indianactsi.org.

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News to Use

Arrow Bike riders raise $125,000 for cancer center and Livestrong

24 Hours of Booty, the Official 24-Hour Cycling Event of Livestrong, raised more than $125,000 last weekend for the Lance Armstrong Foundation and the IU Simon Cancer Center. Thirty-seven teams and 275 riders, including Pedaling Cures, the official team of the IU Simon Cancer Center, participated in this event on June 29 to 30.

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Arrow Looking for resources at the IU School of Medicine?

Find answers in the Resources Section of the IUSM Homepage, located in the lower-right hand corner on the main page. Here you can get answers to common questions about campus maps, technical support, meeting rooms and presentation tools, as well as details on how to communicate your news and messages.

There are also special sections for medical students, with information about student research opportunities, medical school admissions, graduate programs and residences and fellowships, as well as a page for alumni and donors.

Additional information available under the IUSM Resources section includes quick links to adverse weather news, emergency preparedness information, and IUSM policies and procedures.

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Arrow Find funding opportunities with search tools

IUSM researchers interested in identifying funding opportunities in their areas of interest are encouraged to explore these resources:

  • Community of Science: This online search tool assists investigators in identifying funding opportunities. To use this tool, register online and complete the short registration process. Searches may be personalized by selecting the option entitled “launch your workbench." COC provides access to federal, local, corporate, foundation, non-profit and other opportunities using personalized search terms whose results are deliverable via weekly email.
  • NIH Guide (National Institutes of Health): This search tool requires online registration. Registrants may receive discipline-specific funding opportunities deliverable via weekly email.
  • MyNSF (National Science Foundation): This search tool requires online registration. Registrants may receive discipline-specific funding opportunities deliverable via weekly email.
  • Federal Business Opportunities: FedBizOpps is a single point-of-entry for federal government procurement opportunities over $25,000, which include, but are not limited to, presolicitations and special notices for research and service contracts for specific projects and some national centers and surveys not be found in Grants.gov or the Community of Science. To use this tool, visit the Federal Business Opportunities website.

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Arrow Evolution in medical education survey

IU has organized the most extensive survey to date on the roles of evolutionary biology and theory in modern medical education. The survey aims to assess the level of education in evolutionary biology that current health practitioners have and students are receiving, opinions about the utility of evolutionary biology in health practice and research, opinions about when and where training in evolutionary biology might be most appropriate in medical education.

IUSM physicians and medical students are invited to participate. The survey should take less than 15 minutes to complete and one out of every 250 respondents will be randomly selected to receive a new Apple iPod Shuffle.

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Arrow This week on 'Sound Medicine'

This week on "Sound Medicine," Gregory del Zoppo, M.D., professor of medicine in the Division of Hematology at the University of Washington School of Medicine, will discuss research that suggests life-saving medicine administered immediately after a stroke may still be effective as much as six hours after the medical episode.

Also on this week’s program, Sharon Begley, senior health and science correspondent at Reuters, discusses her new report that questions the effectiveness of statins for some heart patients; a analysis of the Food and Drug Administration’s consideration of a plan to issue anthrax kits to millions of Americans to combat bioterrorism; and an exploration of the effectiveness of corporate-run employee wellness programs.

"Sound Medicine," an award-winning radio program that covers controversial ethics topics, breakthrough research studies and the day-to-day application of recent advancements in medicine, is co-produced by IUSM and WFYI Public Radio and underwritten by IU Health Physicians and IUPUI. The program next airs at 2 p.m. Sunday, July 1, on WFYI 90.1 FM, and is also available via podcast and Stitcher Radio for mobile phones and iPads. Reports on Primary Health Care topics are sponsored by Wishard Health Services.

For more information, visit the IUSM Newsroom. Audio will be available on the "Sound Medicine" website.

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Opportunities

Arrow AAMC Readiness for Reform Initiative seeks applications

The Association of American Medical Colleges is seeking applications in four topic areas related to health care delivery redesign and innovations in training. The applications are sought for the AAMC Second Readiness for Reform Innovation Challenge, which will recognize transformational care delivery programs that leverage the uniqueness of academic medicine by integrating innovations in research and education.

The AAMC Readiness for Reform Initiative was launched to assistant AAMC members in assessing their organizational readiness for responding to key elements of reform and provides resources and activities to assist with implementation of these programs, including care delivery redesign and new payment models.

Three institutional winners will be announced at the 2012 AAMC Annual Meeting. Each winner will receive $5,000. For more details or to submit a proposal, visit this AAMC Readiness for Reform Innovation Challenge website.

Submissions are due Friday, Sept. 7

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Arrow Hester Scholarship fund applications — due July 16

The IU Simon Cancer Center Merilyn Hester Scholarship fund was created to assist M.D. and/or Ph.D. students pursuing degrees in biomedical sciences who have demonstrated an interest and potential for conducting pediatric hematology or oncology research and who have not received another type of scholarship for the year. Successful applicants are students who have a strong academic record, outstanding character and well-defined professional goals.

Available funds are for $8,000 a year with the number of awardees determined by the quality of applications and available funds in a given year. Fund distribution details are:

  • M.D. students or M.D./Ph.D. students without tuition assistance; up to $8, 000 applied toward tuition. Start date is Aug 6.
  • All Ph.D. students or M.D./Ph.D. students with tuition assistance; up to $4,000 disbursed to the recipient as a one-time pay increase and up to $4,000 disbursed to the research lab ($2,000 for travel to attend scientific meetings and $2,000 for supplies to offset lab expenses)

To apply, visit this page. The application deadline is Monday, July 16.

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Arrow IU Health Values Grants — applications open

IU Health is seeking applications for its 2013-14 Values Fund grants in the categories of “Medical Research,” “Medical Education” and “The Integration of Religious and Spiritual Dimension in Health Care.”

A letter of intent — as well as any questions — must be submitted for the Integration of Religious and Spiritual Dimensions in Health Care by Monday, Aug. 7. Applications are due by noon Monday, Oct. 15. to the attention to Steven Ivy, Ph.D., senior vice president for Values Ethics, Social, Responsibility and Pastoral Services via Nicole Veal at 317-962-3591 or nveal@iuhealth.org.

The Medical Research and the Medical Education grant — which are two-year awards for $100,000 — are due at noon Monday, Oct. 15. These awards are for $100,000 over two years. Open information sessions for the Medical Research grant program will take place from 10 to 11 a.m. Aug. 23, in the IU Health Methodist Hospital, Room 101, and from 2 to 3 p.m. Tuesday, Sept. 11, in the IU Simon Cancer Center (Barnhill Drive entrance), Room. 101. Open information sessions for the Medical Education grant program will take place from 10 to 11 a.m. Tuesday, Aug. 21, in the IU Simon Cancer Center (Barnhill Drive entrance), Room 101 and from 2 to 3 p.m. Thursday, Sept. 13, in the IU Health Methodist Hospital, Room 433.

Eligible applicants include employees of the IU Health Academic Health Center (i.e. IU Health University, Riley at IU Health, IU Health Saxony and IU Health Methodist) or those with IU Health medical staff, including physicians and health professionals with admitting privileges at the IU Health Academic Health Center.

For more information, or to apply, visit this page.

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Grants & Funding

Arrow Consider a non-modular approach to research budgets

Although the National Institutes of Health’s decision to institute a “modular” approach option to budgets for research awards offered some obvious benefits in the recent past, David S. Wilkes, M.D., executive associate dean for research affairs, and the staff of the Office of Operations' Research Administration group, have concluded that for many investigators, it’s time to revert to non-modular proposals.

The group reports that restrictions and limits of modular budgets have led some investigators to short-change themselves in the belief that proposals with non-modular budgets are much less likely to be approved by study sections. But there is little evidence that this is true for the majority of study sections, Dr. Wilkes said.

A study of all R01 awards made by the NIH to medical schools from October 2008 to February 2011 revealed that one in three was non-modular and they accounted for 44 percent of the direct costs awarded.

In addition, the cost of science continues to rise, so restricting the budget to a modular format can limit an investigator’s ability to obtain the funding needed to complete the proposed research.

At IUSM, the research administration group recently reported these statistics, showing numbers and totals of R01 applications by the school (in millions of dollars) and success rates since 2008:

May 08 – Apr 09

May 09 – Apr 10

May 10 – Apr 11

May 11 – Apr 12

#

$

Rate

#

$

Rate

#

$

Rate

#

$

Rate

Modular

137

51.6

21.9%

150

56.9

16.7%

134

50.6

16.4%

100

38.4

NA

Non-modular

71

43.2

22.5%

57

33.9

19.3%

65

39.9

16.9%

97

64.1

NA

Total

208

94.8

22.1%

207

90.9

17.4%

199

90.5

16.6%

197

102.5

NA

The bottom line, Dr. Wilkes said, is to submit proposals with funding levels that “will truly enable you to do the science you need to do” and therefore use non-modular budgets for NIH grant submissions.

For more information, contact Robert Aull, director of research administration, at 317-274-2325, or raull@iupui.edu.

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Arrow Research Funding Update

The IU Office of the Vice Provost for Research and the Office of the Vice Chancellor for Research offer weekly digests containing information about funding opportunities including those that limit the number of allowable pre-proposal or proposal submissions.

Funding opportunity categories include the sciences, limited submissions, technology and multidisciplinary:

To subscribe to these updates by email, visit this page.

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Kudos

Arrow Honors

Tim Imler, M.D., a dual Regenstrief Institute biomedical informatics and IUSM gastroenterology fellow, received a best talk award at the National Library of Medicine on June 27 for his presentation "Building the Next Generation of Medical Education: Case Based Online Interactive Learning from Drawing Board to the Conference Room.” His Regenstrief fellowship is supported by the National Library of Medicine.

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 At Your Fingertips 

Arrow Continuing Medical Education

The Continuing Medical Education office launched a new and improved website at cme.medicine.iu.edu. In addition to online registration and listings of grand rounds, conferences and courses, the site provides in-depth tools and information for presenters and program developers. Included are forms, tips, links, contacts, maps and other useful resources to make it easier to participate in CME events, prepare a presentation or plan an event.

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Arrow Resources

Want to find a room that has a Polycom hook-up? Need official IUSM templates for your PowerPoint presentation or poster about a guest lecturer? Check out the new “Resources” page on the IUSM web site. This section is accessible from the left-hand side of the school’s home page at medicine.iu.edu.

If you have suggestions of other resources that would be beneficial and could be added to this list, contact the Office of Public and Media Relations at medschl@iupui.edu.

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Arrow MEDTV

The Office of Public and Media Relations manages the MEDTV screens on the medical school campus. This closed-circuit TV system, part of the IUPUI network, presents an opportunity for faculty, staff and students to communicate events and information of interest. It also serves as a source for broadcasting emergency information on campus.

The MedTVs are in public areas of the HITS building, the VanNuys Medical Science Building atrium and corridor/lounge, the Daly Student Center, Fesler Hall, Gatch Hall (formerly Clinical Building), Research II (R2), Walther Hall (R3) and the Cancer Research Institute (R4).

Announcements from departments and offices are welcome. To display your department or office announcement on MedTV, read the MedTV guidelines and find our online submission form at communications.medicine.iu.edu/get-the-word-out/medtv.

For more information, call 317-274-7722.

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Arrow Scope submission guidelines

Scope wants your news items.

The deadline for submission is 8:30 a.m. Thursdays. Scope is published electronically and sent to faculty, staff, students and residents on Fridays, except on holiday weekends. Photos are encouraged with submissions and also may be used on the IUSM homepage or social media channels.

There are three easy ways to submit story ideas or information to Scope:

  • E-mail the information to scopemed@iupui.edu
  • Mail the information to Kevin Fryling, IU Communications, 251 N. Illinois St., North Tower, Suite 300, Indianapolis, IN 46204 (Campus mail; no postage required)
  • Fax your information to 317-278-8722

Contributions submitted by e-mail should be forwarded in 12-point, plain text-format. Word document attachments in lieu of fliers are encouraged.

In the interest of accuracy, please do NOT use:

  • Acronyms
  • Abbreviations
  • Campus building codes (use full, proper name of building and include the room number)
  • Dr. as a preface before names (designate M.D. or Ph.D.)
  • For more info, see the Scope Style Guide (PDF)

To keep the electronic version of Scope as streamlined as possible, only seminars and lectures of general or multidisciplinary interest will be included.

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