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IUSM Scope

March 5, 2010
Volume 14 Number 9 • Indianapolis, Indiana

Topics this issue:

Above the Fold

Arrow Loehrer named director of IU Simon Cancer Center

Cancer physician and researcher Patrick J. Loehrer Sr., MD, has been named director of the Indiana University Melvin and Bren Simon Cancer Center.

Dr. Loehrer is the second person to lead the cancer center since its founding in 1992. He had been serving as interim director since February 2009 following the death of Stephen D. Williams, MD, the founding director.

Dr. Loehrer also will serve as associate dean for cancer research and hold the title HH Gregg Professor of Oncology, pending approval by the board of trustees, at the Indiana University School of Medicine.

For more details, see


Arrow IUSM assumes Monarch LifeSciences contract

The IU School of Medicine has reached an agreement with Monarch LifeSciences that it will assume its contracted research projects within a new proteomics core to be established this spring. Monarch Lifesciences was established in 2003 as INCAPS (Indiana Centers for Applied Protein Sciences).  In 2004, it became Monarch, working on proteomics projects for regional pharma and academic customers.

The new IUSM proteomics core specializes in protein biomarker discovery, biomarker validation, mass spectrometry-based assays, and protein analysis. It will will come under the auspices of the Department of Biochemistry and Molecular Biology. Please refer to for more information about Monarch LifeSciences.


Arrow MMIA offers unique opportunity for high school

Fifty of Indiana’s top high school students will gain special insights into the worlds of science, medicine and genetics during the Molecular Medicine In Action (MMIA) program at IUSM March 7 and 8.

The two-day program, now in its 11th year, grants select students the opportunity to work alongside some of the nation’s top researchers in the labs of the Herman B Wells Center for Pediatric Research.

For more information, click here.


Events & Lectures

Arrow Department of Public Health information session

Faculty, staff and students are invited to attend an information session to learn about the educational programs offered in the IU School of Medicine Department of Public Health. The event from 4:30 to 5:30 p.m. Thursday, March 11, will provide an overview of the MPH Program, the graduate certificate in public health, the PhD in epidemiology, and the Office of Public Health Practice.

The event will be in the Department of Public Health office, room 220, 714 N. Senate Ave.

(corner of Senate and St. Clair streets). Free parking is available in the two lots north of the building. Enter the building on the canal level.

For more information and to RSVP, contact Leah Jansen at or 278-0765.

Visit the website at

Can’t attend the information session in person?

Log on to: to attend the session from your personal computer.


Arrow Grand Rounds: Heart failure epidemic in elderly

Geriatrics Visiting Professor Michael W. Rich, MD, will present “Heart Failure in Older Adults: An Emerging Epidemic of a Fundamentally Different Disease” at Medicine Grand Rounds on Friday, March 12, at 12 noon in Myers Auditorium, Wishard Hospital.

Dr. Rich is a geriatric cardiologist from the Washington University School of Medicine in St. Louis, Mo., and directs the Cardiac Rapid Evaluation Unit at Barnes-Jewish Hospital.


Arrow Point/Counterpoint: Are Human Genes Patentable?

The U.S. Patent Office has allowed patents on DNA sequences related to human genes for many years. A current case is raising the question whether these sequences are eligible for patent protection. Are these man-made inventions subject to patenting or natural phenomena permanently in the public domain?

Plan to attend and hear differing views from academia and industry on this question and whether patents in this area stimulate or suppress research and ultimately human health. This month’s program will be from 11:30 a.m. to 1 p.m. Tuesday, March 16, and speakers will include Kathleen A. Marrs, associate dean for academic affairs, IUPUI School of Science, and

Kevin E. Collins, Esq., associate professor of law, IUPUI School of Law, as well as others to be announced.

Register at There is a $10.00 attendance fee at the Indianapolis location.

Questions? Contact Kristin Jones at 317-278-9973 or


Arrow Gangaraju to present on retinopathy

Shekhar R. Gangaraju, a research associate with the Department of Cellular and Integrative Physiology at the Indiana Center for Vascular Biology and Medicine at the IU School of Medicine, will present “Pathological Angiogenic Signaling and Cellular Therapy in Retinopathy” at 5 p.m. Wednesday, March 17, in room B26, of the VanNuys Medical Science Building.

The program is sponsored by the Eugene and Marilyn Glick Eye Institute.

Dr. Gangaraju is a cell biologist with experience in biochemistry, molecular biology and pharmacology. His doctorate in the field of reproductive molecular biology is from the National University of Singapore. He received his master’s degree at Kasturba Medical College in Manipal, India and his bachelor’s degree at Osmania University in Hyderabad, India. He joined IUSM in 2004 as been a post doctoral fellow and is now research associate.


Arrow Registration open for Research Coordinator Education Program

An educational program for research coordinators will be offered by IUSM and the Indiana Clinical and Translational Sciences Institute (CTSI), Roudebush VA Research and Development and the IU School of Nursing Office of Lifelong Learning on March 18 and 19.

This program is mandated for all new research coordinators at IUSM with less than two years experience coordinating studies on the IUPUI/Clarian campuses.  The program is designed to provide specific guidance about how to conduct and coordinate clinical drug studies at IU.

While the program targets the new study coordinator, experienced coordinators and young investigators at IUSM, Clarian Health, School of Dentistry, School of Nursing, Roudebush VA and Wishard Hospitals often attend and find the content useful and their skills strengthened.

The cost of the program is $290. Payments from grant accounts or other IU accounts are acceptable.

The program will be held in the Riley Outpatient Center, lower level, classrooms A and B. For complete information and a registration form, go to and click on “Research Coordinator Education Program.”

Contact the Office of Lifelong Learning at 274-7779 or email if you have questions.


Arrow Schneir to keynote CACR Higher Education Security Summit

Register now for the 2010 Center for Applied Cybersecurity Research (CACR) Higher Education Security Summit at

The Thursday, April 1, summit is aimed at security, law and information assurance professionals within the higher education, law enforcement, legal, government, and non-profit sectors. Renowned security guru Bruce Schneier will headline the event with an address on "Security, Privacy, and the Generation Gap."
A frequent security critic and commentator, Schneier has testified before Congress and authored bestselling books including Applied Cryptography, Secrets and Lies, Beyond Fear, and Schneier on Security.
Advance registration and confirmation is required to attend. For a complete look at the program or to register, see


Arrow Breast cancer screening topic of 10th annual Merritt Lecture

The 10th Annual Doris H. Merritt, MD Lectureship in Women's Health will be Wednesday, April 28, in Joseph Walther Hall (R3), room 203 from 8:15 – 10:30 a.m.  This year's lecture featuring Carol Lee, MD, will focus on the recent controversy in breast cancer screening guidelines.  Dr. Lee, who helped write the ACR's rebuttal to the recent U.S. Preventive Services Task Force guidelines recommending mammograms to start at age 50, will be lecturing on "Screening for breast cancer with mammography, ultrasound and MRI: Who, When, and Why".

Dr. Lee is an attending radiologist at Memorial Sloan-Kettering Cancer Center in New York and professor of radiology at Weill Medical College, Cornell University. She received her MD degree from Yale University School of Medicine and did her residency in diagnostic radiology at Yale New-Haven Hospital. She has been specializing in breast imaging for more than 25 years and has particular interest in magnetic resonance imaging of the breast. She is currently chair of the Commission on Breast Imaging of the American College of Radiology and is immediate past president of the Society of Breast Imaging. 

A panel discussion, facilitated by Lee Learman, MD, chair of the IUSM Department of Obstetrics and Gynecology, will immediately follow. The panel will address the broad concepts and principles that influence screening practices from a number of perspectives including women's health primary care, medical ethics, cancer policy research, medical oncology and behavioral research.   The panel will include Victoria Champion, DNS, RN, Thomas Imperiale, MD, Peter Schwartz, MD, PhD, Anna Maria Storniolo, MD, and Ann Zerr, MD.

For more information on the Doris H. Merritt, MD Lectureship and the IU National Center of Excellence in Women’s Health go to


Grants & Funding

Arrow Grants and Awards February 2010

The following list includes new and competing research awards received during the month (excluding commercial projects). Amount shown is based on the first budget period/year.

PI Agency Type Project Title Begin End Total
Kenneth G. Cornetta NIH-NCRR New Automated Nucleic Acid Extractor System: AutoGenFlex Star/AutoGen Quick-Gene 810 2/20/10 2/19/11 159,460
Howard J. Edenberg Res Fdn St Univ NY Contin/
Collaborative Study on the Genetics of Alcoholism (COGA) 9/1/09 8/31/10 1,529,079
Sherif Shafik Farag NIH-NCI New Multiple kinase target inhibition with EMND-2076 in multiple myeloma 2/1/10 1/31/11 319,550
David A. Flockhart NIH-NICHD New Indiana PREGMED 2/1/10 12/31/10 983,372
Tatiana M. Foroud Univ Of Pennsylvania New Genome-wide association analyis of Alzheimer's disease 9/30/09 8/31/10 91,624
Tatiana M. Foroud Northwestern Univ New GENORM: Collection of Genotypic Data for the NIH Toolbox Norming Sample 9/30/09 8/31/10 390,510
Tatiana M. Foroud Univ Of Rochester Contin/
Cooperative Huntington's Disease Observational Research Trial (COHORT) 7/1/09 6/30/10 136,078
David Michael Haas NIH-NICHD New Dissecting the genetic etiology of preterm birth in nulliparous women 1/10/10 12/31/11 187,920
Johnny J. He NIH-NIDA New HIV interaction with drugs of abuse and adult neurogenesis 4/1/10 3/31/11 192,500
Takako Kondo Natl Org Hearing Res Fdn New Axon guidance cues for stem cell replacement in auditory neuropathy 2/1/10 1/31/11 20,000
Manjusha Kumar Children'S Hospital Boston Contin/
The North American Chronic ITP Registry 10/1/09 9/30/10 1,000
Theodore F. Logan Hoosier Oncology Gro New Phase I/II Study of BNC105P in Combination with  Everolimus or Following Everolimus For Progressive Metastatic Clear Cell Renal Cell Carcinoma Following Prior Tyrosine Kinase Inhibitors:  Hoosier Oncology Group GU09-145 1/1/10 12/31/10 219,569
Kristine M Mosier Rehab Inst Res Corp New Functional Remapping of Hand Movements 9/1/09 8/31/10 166,770
Louis Martin Pelus NIH-NHLBI New Role of PGE2 and other eicosanoids in hematopoietic stem cell function 1/29/10 11/30/10 385,000
Brenda Bradley Poindexter Duke University New Pharmacokinetics and Safety of Piperacillian-Tazobactam in Neonates 1/21/10 6/30/11 131,000
Lawrence Andrew Quilliam Lam Foundation New Targeting the Unfolded Protein Response to Treat LAM 1/15/10 1/14/12 50,000
Douglas Kevin Rex Mayo Clinic New Real-time feedback to improve colonoscopy quality. 9/1/09 5/31/10 2,137
Ravi Prakash Sahu Am Inst Cancer Res New Role of oxGPCs/PAFR in BITC mediated suppression of melanoma. (AICR grant '09A062') 1/1/10 12/31/10 37,998
Fletcher Alan White Northwestern Univ New HIV-1 Infection and the Peripheral Nervous System 11/1/09 4/30/10 1,562
Fletcher Alan White Loyola University New Chemokine-mediated Modulaton of Opioid-induced Pain 10/1/09 5/31/10 252,070


Arrow Faculty research interest search tool available

Need to find an IUSM faculty researcher whose interests match or complement yours? The Office of Decision Support has made available the faculty research interest search tool, a searchable database that uses ASR data provided by faculty members in regards to research interests, grants, and publications.  The data is updated annually.

The database search tool is available at


Arrow Research Funding Update

The IU Office of the Vice Provost for Research and the Office of the Vice Chancellor for Research offer a weekly digest containing information about funding opportunities including those that limit the number of allowable pre-proposal or proposal submissions. Digests are published on Wednesdays but may be sent more frequently if deadlines are urgent.

View the current Research Funding Update.



Arrow Deadline extended for Vision Research Symposium abstracts

The deadline to submit abstracts for the April 10 Eugene and Marilyn Glick Eye Institute’s Vision Research Symposium has been extended to Tuesday, March 9.  Information on the process can be found at

The Vision Research Symposium will focus on clinical and basic science as related to the eye and vision. The purpose of the meeting is to bring together scientists from diverse disciplines and institutions within Indiana in order to share ideas and promote a better understanding of diseases that may cause vision loss and blindness, and to improve treatment.


Arrow Call for proposals: CACR grants for faculty, staff

The Center for Applied Cybersecurity Research is soliciting grant proposals for research in information security at Indiana University. Funds may be requested by any faculty member, professional staff member, or other full-time employee of IU.

Applications should be submitted by 5 p.m. on Wednesday, March 31. Awards will be announced in early May and funds will be available beginning July 1.

Proposals must address some aspect of information security or assurance; combine the strengths of two or more of the distinct IU resources (e.g., informatics, professional schools, ANML, REN-ISAC, the Global NOC, life sciences), and demonstrate a high potential for attracting future external funding.

The grants are intended to foster collaboration within IU and support the early development of innovative research likely to compete favorably for competitive external funding in the future.

For more information and application instructions, visit


News to Use

Arrow User Survey: Help improve UITS services

Were you selected to take part in the annual UITS user survey? If so, please take a moment to share your thoughts. Your observations and opinions are critical to helping us evaluate our services.

Your invitation included survey instructions for responding online – the questions aim to assess your level of satisfaction with UITS computing and telephone services, as well as with support for instruction, research, and administration.

Your past input has helped us tailor UITS services and support to your needs. We appreciate your ongoing feedback.

View previous UITS Survey findings at


Arrow Is the People Mover running?

Clarian has made the People Mover status available from the web at


Arrow This week on Sound Medicine

Tune in at 2 p.m. Sunday, March 7, or 8 p.m. Tuesday, March 9, to Sound Medicine, the award-winning weekly radio program co-produced by IUSM and WFYI Public Radio (90.1FM) in Indianapolis.

This weekend, John Nance, JD, author of, Why Hospitals Should Fly: The Ultimate Flight Plan to Patient Safety and Quality Care, will discuss how hospitals can avoid medical errors by following airline safety and quality measures.

Theresa Guise, MD, professor of medicine and oncology at IUSM, will discuss a new study that suggests use of bisphosphonates – bone-strengthening drugs – may also reduce the risk for breast cancer.

Allen Taylor, MD, director of advance cardiovascular imaging at Washington Hospital Center and professor of medicine at the Uniformed Services University School of Medicine near Washington D.C., will explain his study that found how niacin can help increase levels of good cholesterol.

Author Rebecca Skloot will discuss her new book, The Immortal Life of Henrietta Lacks, which explores the life of an African-American woman whose cells were taken without permission in the 1950’s and cultured for testing and have continued to be grown and used for research worldwide.

Wright State University medical students will discuss Radio Rounds, a new medical podcast hosted and produced by them.

In this week’s Sound Medicine “Checkup,” Jeremy Shere, Ph.D., will explore blueberries used for a brain boost.

Archived editions of Sound Medicine as well as other helpful information can be found at

Sound Medicine is underwritten by Clarian Health, IU Medical Group and Indiana University-Purdue University Indianapolis. Primary care segments are underwritten by Wishard Health Services.



Arrow Health Care Heroes 2010

Each year, the Indianapolis Business Journal accepts nominations for the Health Care Heroes awards. From the list of nominees, three Heroes are selected as finalists. Those three are in the spotlight at the breakfast awards ceremony and one person or group is chosen as the winner in each of the five categories.

This year, IUSM was well represented with finalists in three categories at the March 5 breakfast.

The winner of the Physician category was patient advocate and psychiatrist Alan D. Schmetzer, MD, professor of psychiatry. An IUSM faculty member since 1986, Dr. Schmetzer has spent the past 40 years caring for patients with psychiatric disorders and working to increase the understanding of the disorders and programs available. He began his career in emergency psychiatric care at Midtown Community Mental Health Center and along the way served as superintendent of Larue Carter Hospital. He also is actively involved in educating medical students and residents as director and later vice-chair of psychiatry education.

A finalist in the Physician category Martin B. Kleiman, MD, the Ryan White Professor of Pediatrics at IUSM and a pediatric infectious disease physician at Riley Hospital, diagnosed Ryan White with AIDS in 1984 and since then has worked tirelessly to care for children with HIV/AIDS and educate pregnant Hoosiers about treatments and help prevent babies from contracting the disease. He has led the expansion of infectious disease treatment at Riley.

The winner of the Non-Physician category was Matthew Aalsma, PhD, associate professor of psychology and pediatrics in the Section of Adolescent Medicine. His research and efforts to ensure that Indiana provides care for the physical and mental health of young offenders has resulted in legislative changes in Medicaid rules. In addition to his interest in juveniles in the justice system, Dr. Aalsma counsels youth and conducts screenings for the Marion County juvenile justice system.

L. Daniel Wurtz, MD, was a finalist in the Advancements in Health Care category. An IUSM  professor of orthopaedic surgery at Riley Hospital, Dr. Wurtz has focused on limb-saving research for children with cancer. He has spearheaded treatment with a device known as Repiphysis – a metal prosthesis that can be inserted into a limb to replace bone lost to a tumor. As the child grows, the device can be painlessly lengthened without the need for invasive surgery.

The Health and Hospital Corporation of Marion County was the winner of the Community Achievement in Health Care category for its successful referendum to construct a new 1.2 million square foot, 315-bed complex to replace antiquated Wishard facilities. The award was accepted by Lisa Harris, MD, the John F. Williams Jr., MD Scholar, associate professor of medicine and the director and associate dean of Wishard Health Services, and Matt Gutwein, president and CEO of Health and Hospital.


Arrow Darnell Award recipient

Stephanie Nothelle is the recipient of the Dr. Jeffrey C. Darnell Medical Student Geriatrics Achievement Award for 2010.  The purpose of this IU Geriatrics award is to recognize a medical student for outstanding service and leadership in the care of older adults.

Nothelle is a third-year medical student who plans to become a geriatrician. The award will be presented to her on Friday, March 12, at noon, immediately preceding Medicine Grand Rounds in the Wishard Myers Auditorium.  Grand Rounds will be delivered that day by Visiting Professor Mike Rich, MD, a geriatric cardiologist.

As the award recipient, Nothelle will attend the American Geriatrics Society Annual Meeting in May and will present her research project entitled “Medical Students’ Perspectives about Participation in a Geriatrics Elective.” Stephanie is the current president of the Student Geriatrics Interest Group.


Arrow Trustees Teaching Award recipients

Recipients of the 2010 IUSM Trustees Teaching Awards, who will be formally recognized at commencement:

2010 Trustee Teaching Award Recipients
Recipient Department
Tracy Anthony, Ph.D. Evansville Campus
Robert Bacallao, M.D. Medicine
Matt Bair, M.D. Medicine
Byron Batteiger, M.D. Medicine
Andrew Beckman, M.D. Emergency Medicine
Tonya Bergeson-Dana, Ph.D. Otolaryngology
Timothy Brady, M.D. Medicine
Frances Brahmi, Ph.D. Ruth Lilly Medical Library
Randy Brutkiewicz, Ph.D. Microbiology & Immunology
Aaron Carroll, M.D.  Pediatrics
Dylan Cooper, M.D. Emergency Medicine
Theodore Cummins, Ph.D. Pharmacology & Toxicology
Shashank Dave, D.O. Physical Medicine & Rehabilitation
Thomas Davis, M.D., Ph.D. Pathology & Laboratory Medicine
Mark Falimirski, M.D. Surgery
Irmina Gradus-Pizlo, M.D. Medicine
Rajesh Gulati, M.B.B.S. Medicine
Richard Gunderman, M.D., M.P.H, Ph.D Radiology
Sandeep Gupta, M.D. Pediatrics
Maureen Harrington, Ph.D. Biochemistry & Molecular Biology
Mitchell Harris, M.D. Pediatrics
John Hasewinkel, M.D. Anesthesia
David Hass, M.D. Obstetrics & Gynecology
Paul Helft, M.D. Medicine
Michelle Howenstine, M.D. Pediatrics
Thomas Klausmeier, M.D. Pediatrics
Regina Kreisle, M.D., Ph.D. Lafayette Campus
Glen Lehman, M.D. Medicine
Michael Lykens, M.D. Medicine
Lawrence Mark, Ph.D. Dermatology
Bruce Martin, Ph.D. Bloomington Campus
Paula Mathewson, M.D. Psychiatry
Philip Merk, M.D. Pediatrics
James Mitchell, M.D. Anesthesia
J. Andrew Parr, M.D. Orthopaedic Surgery
Joseph Prahlow, M.D. South Bend Campus
Michael Risinger, M.D. Neurology
Jerry Rushton, M.D., M.P.H. Pediatrics
Alan Schmetzer, M.D. Psychiatry
Himanshu Shah, M.D. Radiology
Scott Shapiro, M.D. Neurological Surgery
Ronald Shew, Ph.D. Anatomy & Cell Biology
Clark Simons, M.D. Surgery
Gregory Steele, DrPH., M.P.H. Public Health
Ernest Talarico, Ph.D. Northwest Campus
Virginia Thurston, Ph.D. Medical & Molecular Genetics
Laura Torbeck, Ph.D. Surgery
Johnathan Tune, Ph.D. Cellular & Integrative Physiology
Joel Vilensky, Ph.D. Fort Wayne Campus
T. Robert Vu, M.D. Medicine
Gabi Waite, Ph.D. Terre Haute Campus
Laurence Walsh, M.D. Neurology
James Williams, Ph.D. Anatomy & Cell Biology

For more information regarding the Trustee Teaching Awards, please visit the website:


 At Your Fingertips 

Arrow Continuing Medical Education

The Continuing Medical Education office launched a new and improved website at In addition to online registration and listings of grand rounds, conferences and courses, the site provides in-depth tools and information for presenters and program developers. Included are forms, tips, links, contacts, maps, and a host of other handy resources to make it easier to participate in CME events, prepare a presentation or plan an event.


Arrow Resources

Want to find a room that has a Polycom hook-up? Need official IUSM templates for your PowerPoint presentation or poster about a guest lecturer? Check out the new “Resources For” page on the IUSM web site. Resources For is accessible from the school’s home page ( – look on the right-hand side of the page.

If you have suggestions of other resources that would be beneficial and could be added to this list, contact the Office of Public and Media Relations at


Arrow MedTV

The Office of Public and Media Relations now manages the MedTV screens on the medical school campus. This closed-circuit TV system, part of the IUPUI network, presents a wonderful opportunity for faculty, staff and students to communicate events and information of interest to others. It also serves as a source for broadcasting emergency information on campus.

The MedTVs are located in public areas of the HITS building, the VanNuys Medical Science Building atrium, the Daly Center, Research II, Walther Hall (R3) and the Cancer Research Institute (R4).

Announcements from departments and offices are welcome. To have your department or office announcements posted on MedTV, please read the MedTV guidelines: Questions? Phone 274-7722.


Arrow Scientific Calendar online

A comprehensive listing on IUSM seminars, lectures and Grand Rounds can be accessed at the new Scientific Calendar website. To place items on the Scientific Calendar, please forward them to Kelli Diener at


Arrow Scope submission guidelines

Scope wants your news items.

The deadline for submission is 8:30 a.m. on Thursdays. Scope is published electronically and sent to faculty, staff, students, and residents on Fridays (except on holiday weekends when it is published on the following Monday).

There are three easy ways to submit story ideas or information to Scope:

  • e-mail the information to
  • mail the information to Kevin Fryling, 1110 W. Michigan, LO 401, IUPUI
  • fax your information to (317) 278-8722

Contributions submitted by e-mail should be forwarded in 12 point, plain text format. Word document attachments in lieu of fliers are encouraged.

In the interest of accuracy, please do NOT use:

  • acronyms
  • abbreviations
  • campus building codes (use full, proper name of building and include the room number)
  • Dr. as a preface before names (designate MD or PhD)

To keep the electronic version of Scope as streamlined as possible, only seminars and lectures of general or multidisciplinary interest will be included.